| Brand Name (Generic Name) | Breztri Aerosphere™ [brez-TREE] (budesonide-glycopyrrolate-formoterol fumarate) |
| How Supplied | Pressurized metered dose inhaler with 28 or 120 inhalations, containing budesonide (160 mcg), glycopyrrolate (9 mcg), and formoterol fumarate (4.8 mcg) per inhalation |
| Therapeutic Class | Combination of a corticosteroid, anticholinergic, and long-acting beta2-adrenergic agonist |
| Approved Indication | Maintenance treatment of patients with chronic obstructive pulmonary disease |
| Usual Dosing | Two oral inhalations twice daily. Rinse mouth with water without swallowing after each use. |
| Select Drug Interactions | Strong cytochrome P450 3A4 inhibitors (e.g., clarithromycin) may increase exposure to budesonide. Diuretics, xanthine derivatives or steroids may potentiate hypokalemia or ECG changes. MAO inhibitors and tricyclic antidepressants may potentiate effect of formoterol on cardiovascular system. Beta-blockers may produce severe bronchospasm. |
| Most Common Side Effects | Upper respiratory tract infection, pneumonia, back pain, oral candidiasis, influenza, muscle spasm, urinary tract infection, cough, sinusitis, and diarrhea |
| Miscellaneous | Not for acute bronchospasm or treatment of asthma. Severe hepatic impairment may increase systemic exposure of budesonide and formoterol. |
| Website | https://www.breztri.com |
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